Mpox (Monkeypox) Vaccine

What You Need To Know

⚠Click here to book a first dose mpox (monkeypox) vaccine appointment ⚠
Update 24th February 2023: The HSE monkeypox vaccine booking portal remains open with good availability in most vaccine centres up to the end of March. The booking portal can be used to book your first dose of the vaccine. If you already had your first dose but need to book a second dose mpox vaccine appointment, you can do that by calling HSE Live on 1800 700 700. 

Mpox, the new name for monkeypox: In line with the recent World Health Organisation recommendation, we are updating all of our resources and webpages to ‘mpox’, the new term for monkeypox. 

Who can get a mpox vaccine?

You can get a mpox vaccine if you are a gay or bisexual man or transgender person and one of the following applies to you:

  • You have been diagnosed with a bacterial STI (sexually transmitted infection) in the past 6 months. For example gonorrhoea, syphilis or chlamydia.
  • You have been diagnosed with genital herpes for the first time in the past 6 months.
  • You have had 3 or more sexual partners in the past 3 months.
  • You have had group sex in the past 6 months.
  • You have had sex in a sex-on-premises venue in the past 6 months — this can include a sauna, dark room or sex club.

At this time, the mpox vaccine is not considered necessary if you have had mpox infection before.

If you have received a first dose of the mpox vaccine already, you can book your second dose online. Wait 4 weeks since your first dose and tell your vaccinator that this is your second dose. 

How do I book an appointment for a mpox vaccine?

If you are over 18 and you meet the criteria above you can book a first dose monkeypox vaccine at If you have received your first dose at least 28 days ago and do not have an appointment for your second dose, you can book an appointment by calling HSE Live on 1800 700 700.

If you are between 16 and 18 and meet the criteria above, you can book an appointment by calling HSE Live on 1800 700 700.

What questions will I be asked?

The HSE will not ask you to confirm or prove you meet the at-risk criteria. You will not be asked about your sexual practices or sexual history when you book online, over the phone or when you are being vaccinated. This criteria is set so that you can self-assess your risk and decide if you would benefit from being vaccinated against mpox.

You will be asked for your PPS number but this is optional. The monkeypox vaccine is available to you whether you have a PPS number or not and regardless of your immigration status.

You may be asked to show a form of ID when attending your monkeypox vaccine.

How is the mpox vaccine given?

There are 2 ways to get the vaccine:

  1. by injecting into your upper arm (subcutaneous)
  2. by injecting between layers of skin in your arm (intradermal) — this is a smaller dose but gives you the same protection.

Most people will receive the vaccine intradermally on their forearm. However, you can request that your vaccine is administered on your upper arm if you would prefer to receive it that way.

If you are aged 16 to 18, you will get the vaccine through an injection in your upper arm.
If you have keloid scars, you will get the vaccine through an injection in your upper arm.

How many doses of the vaccine will I get?

If you are receiving a vaccine because you are in an at-risk group, you will get 2 doses of the mpox vaccine, 28 days apart.

If you have received the first dose of the mpox vaccine elsewhere, you can be given your second dose 28 days after you got your first. 

If you had a smallpox vaccine before, you only need 1 dose of the vaccine. But if you have a weak immune system, you will need 2 doses. Vaccines may be less effective for you than other people.

If you are a close contact of someone with mpox, you will get 1 dose of the monkeypox vaccine. Some close contacts will get 2 doses or will be called forward for a second dose after some time.

When will the vaccine start working?

It takes 14 days after you complete your course of vaccine for it to work.

There is a chance you might still get mpox, even if you have had the vaccine. But if you do, it may reduce any symptoms of the infection.

Are there any side effects?

The most common side effects of the vaccine are:

  • headache
  • nausea
  • muscle pain (myalgia)
  • tiredness
  • reactions where you got the vaccine, including pain, redness, swelling, hardening and itching

These may affect more than 1 in 10 people.

Report any harmful effects to the Health Products Regulatory Authority (HPRA)

You can report it yourself, or your doctor or family member can do that for you.

Read more about the side effects in the information leaflet –

Can I take other vaccines around the same time?

You can take a COVID-19 vaccine in the days or weeks before your mpox vaccine. However, you should wait 4 weeks after your monkeypox vaccine if you intend to take a COVID-19 vaccine. 

You may take other vaccines such as the seasonal flu vaccine at any time before or after a mpox vaccine. 

For more information, check the HSE FAQ document below.

Where can I get more information?

The HSE has developed a comprehensive FAQ document which you can download here

As soon as new information is made available about vaccination, we’ll share it with you here and on social media. If you have questions about monkeypox vaccination, get in touch with our outreach team

It’s important to get information from a reliable source such as the Health Service Executive (HSE) or Health Protection Surveillance Centre (HPSC). At MPOWER, we are working with these agencies on the response to mpox with our colleagues in the Gay Health Network. We’ll be updating the information on our website and through social media as the situation changes.

Health Protection Surveillance Centre – Monkeypox

Health Service Executive – Monkeypox – Monkeypox information

Scroll to Top